Anne Marie Roche, who feels empty inside after the husband she was separated from dies, invites other widows to her book store to make a list of twenty wishes, the fulfillment of which leads each woman into unexpected relationships or friendships.

Three diverse women find their lives converging on Orion Point as they discover the truth about lost love and buried secrets and the strength to face the future.

Katherine Givens, following the wishes of her friend Annie who has died of ovarian cancer at the age of fifty six, calls together four other women who have been important in Annie's life, and together they travel across the country sprinking Annie's ashes in designated places, and reevaluating their own lives and choices.